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MGP004465

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group XVI
Protein EntryHRSL3_HUMAN
UniProt IDP53816
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=300 uM for dipalmitoyl-PC {ECO:0000269|PubMed:19615464}; Vmax=2.57 umol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269|PubMed:19615464}; Vmax=267 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269|PubMed:19615464}; pH dependence: Optimum pH is 9. {ECO:0000269|PubMed:19615464};
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Catalytic ActivityPhosphatidylcholine + H(2)O = 2- acylglycerophosphocholine + a carboxylate.
FunctionExhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity). N- and O- acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity. {ECO:0000250, ECO:0000269|PubMed:17374643, ECO:0000269|PubMed:19615464}.
InductionBy IFNG and IRF1. {ECO:0000269|PubMed:11973642}.
InteractionP30153:PPP2R1A; NbExp=7; IntAct=EBI-746318, EBI-302388;
SimilarityBelongs to the H-rev107 family. {ECO:0000305}.
Subcellular LocationCytoplasm. Cytoplasm, perinuclear region {ECO:0000250}. Membrane; Single-pass membrane protein.
SubunitInteracts with PPP2R1A; this interaction might decrease PP2A activity. {ECO:0000269|PubMed:17374643}.
Tissue SpecificityWidely expressed. low expression, if any, in hematopoietic cells and thymus. In testis, confined to round spermatids. Expressed in normal ovarian epithelial cells. Down- regulated in some ovarian carcinomas and testicular germ cell tumors. {ECO:0000269|PubMed:11526504, ECO:0000269|PubMed:11973642, ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:9771974}.
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