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MGP004466

UniProt Annotations

Entry Information
Gene NameLSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Protein EntryLSM6_HUMAN
UniProt IDP62312
SpeciesHuman
Comments
Comment typeDescription
FunctionComponent of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). {ECO:0000250}.
InteractionP62310:LSM3; NbExp=3; IntAct=EBI-373310, EBI-348239; Q9Y4Y9:LSM5; NbExp=4; IntAct=EBI-373310, EBI-373007; Q9UK45:LSM7; NbExp=4; IntAct=EBI-373310, EBI-348372;
SimilarityBelongs to the snRNP Sm proteins family. SmF/LSm6 subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12515382}. Nucleus {ECO:0000250}.
SubunitComponent of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven- membered ring structure with a doughnut shape. {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:12515382}.
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