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MGP004469

Record overview

MGPD IDMGP004469
Gene ID11165
SpeciesHomo sapiens (Human)
Gene Namenudix (nucleoside diphosphate linked moiety X)-type motif 3
Gene Symbol NUDT3
SynonymsDIPP; DIPP1; DIPP-1;
Alternate namesdiphosphoinositol polyphosphate phosphohydrolase 1; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1; nucleoside diphosphate-linked moiety X motif 3; nudix motif 3;
Chromosome6
Map Location6p21.2
EC Number3.6.1.52
SummaryNUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
OrthologsView orthologs and multiple alignments for NUDT3

Proteins

diphosphoinositol polyphosphate phosphohydrolase 1
Refseq ID:NP_006694
Protein GI:5729804
UniProt ID:O95989
mRNA ID:NM_006703
Length:172
RefSeq Status:
MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIV
TEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR
 
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