MGP Database

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MGP004470

UniProt Annotations

Entry Information
Gene Namefollistatin-like 1
Protein EntryFSTL1_HUMAN
UniProt IDQ12841
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q12841-1; Sequence=Displayed; Name=2; IsoId=Q12841-2; Sequence=VSP_055075; Note=No experimental confirmation available.;
FunctionMay modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity). {ECO:0000250}.
InteractionP12643:BMP2; NbExp=2; IntAct=EBI-2349801, EBI-1029262; P08571:CD14; NbExp=3; IntAct=EBI-2349801, EBI-3905196; Q14689:DIP2A; NbExp=4; IntAct=EBI-2349801, EBI-2564275; A4D1W7:INHBA; NbExp=2; IntAct=EBI-2349801, EBI-8307749; P01137:TGFB1; NbExp=2; IntAct=EBI-2349801, EBI-779636;
SimilarityContains 1 follistatin-like domain. {ECO:0000305}.
SimilarityContains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule:PRU00798}.
SimilarityContains 1 VWFC domain. {ECO:0000305}.
SimilarityContains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationSecreted {ECO:0000305}.
SubunitInteracts with SCN10A.
Tissue SpecificityOverexpressed in synovial tissues from rheumatoid arthritis. {ECO:0000269|PubMed:15638044}.
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