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MGP004471

UniProt Annotations

Entry Information
Gene NamePC4 and SFRS1 interacting protein 1
Protein EntryPSIP1_HUMAN
UniProt IDO75475
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=p75, PSIP1; IsoId=O75475-1; Sequence=Displayed; Note=Less active than isoform 2 as transcriptional coactivator, but more abundant in cells.; Name=2; Synonyms=p52, PSIP2; IsoId=O75475-2; Sequence=VSP_014297, VSP_014298; Name=3; IsoId=O75475-3; Sequence=VSP_044435;
DiseaseNote=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
DomainResidues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).
FunctionTranscriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}.
InteractionP04585:gag-pol (xeno); NbExp=21; IntAct=EBI-1801773, EBI-3989067; P63165:SUMO1; NbExp=4; IntAct=EBI-1801773, EBI-80140;
PtmCitrullinated by PADI4. {ECO:0000250}.
SimilarityBelongs to the HDGF family. {ECO:0000305}.
SimilarityContains 1 PWWP domain. {ECO:0000255|PROSITE- ProRule:PRU00162}.
Subcellular LocationNucleus {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.
SubunitMonomer. Interacts with IFRD1/PC4. Isoform 2 interacts with SFRS1. Isoform 1 interacts POGZ and CDCA7L. Isoform 1 interacts with lentiviral integrase and acts as a chromatin tethering factor to the chromosomal DNA. Isoform 1 interacts in particular with the human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome. Isoform 1 interacts also with HIV-2 IN. Isoform 2 does not interact with HIV-1 IN. {ECO:0000269|PubMed:15895093, ECO:0000269|PubMed:16260736, ECO:0000269|PubMed:19244240, ECO:0000269|PubMed:9822615, ECO:0000269|PubMed:9885563}.
Tissue SpecificityWidely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9822615}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PSIP1ID405ch9q22.html";
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