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MGP004476

Record overview

MGPD IDMGP004476
Gene ID11185
SpeciesHomo sapiens (Human)
Gene Nameindolethylamine N-methyltransferase
Gene Symbol INMT
SynonymsTEMT;
Alternate namesindolethylamine N-methyltransferase; amine N-methyltransferase; aromatic alkylamine N-methyltransferase; arylamine N-methyltransferase; indolamine N-methyltransferase; nicotine N-methyltransferase; thioether S-methyltransferase;
Chromosome7
Map Location7p14.3
EC Number2.1.1.49
SummaryN-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]
OrthologsView orthologs and multiple alignments for INMT

Proteins

indolethylamine N-methyltransferase isoform 1
Refseq ID:NP_006765
Protein GI:66933018
UniProt ID:O95050
mRNA ID:NM_006774
Length:263
RefSeq Status:
MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKK
EPGAYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLR
LPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQSYSVTNAANNGVCFIVARKKPGP
 
indolethylamine N-methyltransferase isoform 2
Refseq ID:NP_001186148
Protein GI:312836856
UniProt ID:O95050
mRNA ID:NM_001199219
Length:262
RefSeq Status:
MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKE
PGAYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRL
PSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQSYSVTNAANNGVCFIVARKKPGP
 
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