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MGP004493

UniProt Annotations

Entry Information
Gene Namesolute carrier family 6 (amino acid transporter), member 14
Protein EntryS6A14_HUMAN
UniProt IDQ9UN76
SpeciesHuman
Comments
Comment typeDescription
DiseaseNote=Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals.
FunctionMediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner. {ECO:0000269|PubMed:10446133}.
MiscellaneousTransport inhibited by BCH (2-aminobicyclo-[2.2.1]- heptane-2-carboxylic acid).
SimilarityBelongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityLevels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis. {ECO:0000269|PubMed:10446133}.
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