MGP Database

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MGP004504

UniProt Annotations

Entry Information
Gene Namesolute carrier organic anion transporter family, member 2B1
Protein EntrySO2B1_HUMAN
UniProt IDO94956
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=1b, FL; IsoId=O94956-1; Sequence=Displayed; Name=2; IsoId=O94956-2; Sequence=VSP_006147, VSP_006148; Note=No experimental confirmation available.; Name=3; Synonyms=1e, Short; IsoId=O94956-3; Sequence=VSP_054109; Note=Functional transporter. Predominant isoform in liver, expression at promoter is regulated by HNF4alpha.; Name=4; IsoId=O94956-4; Sequence=VSP_054110; Note=No experimental confirmation available.;
FunctionMediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. {ECO:0000250}.
Sequence CautionSequence=BAA74903.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the organo anion transporter (TC 2.A.60) family. {ECO:0000305}.
SimilarityContains 1 Kazal-like domain. {ECO:0000255|PROSITE- ProRule:PRU00798}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityIsoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver. {ECO:0000269|PubMed:23531488}.
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