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MGP004516

UniProt Annotations

Entry Information
Gene Namenidogen 2 (osteonidogen)
Protein EntryNID2_HUMAN
UniProt IDQ14112
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14112-1; Sequence=Displayed; Name=2; IsoId=Q14112-2; Sequence=VSP_038779, VSP_038780; Note=No experimental confirmation available.;
FunctionCell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.
PtmHighly N- and O-glycosylated. {ECO:0000269|PubMed:19159218}.
Sequence CautionSequence=BAA13087.1; Type=Frameshift; Positions=54, 68, 150, 172; Evidence={ECO:0000305}; Sequence=BAA24112.1; Type=Frameshift; Positions=54, 68, 150, 172; Evidence={ECO:0000305};
SimilarityContains 1 NIDO domain. {ECO:0000255|PROSITE- ProRule:PRU00570}.
SimilarityContains 1 nidogen G2 beta-barrel domain. {ECO:0000255|PROSITE-ProRule:PRU00348}.
SimilarityContains 2 thyroglobulin type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00500}.
SimilarityContains 5 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 5 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}.
Subcellular LocationSecreted, extracellular space, extracellular matrix, basement membrane.
SubunitInteracts with LAMA2 (By similarity). Interacts with COL13A1. {ECO:0000250, ECO:0000269|PubMed:11956183}.
Tissue SpecificityHeart, placenta and bone. Less in pancreas, kidney and skeletal muscle.
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