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MGP004518

UniProt Annotations

Entry Information

Gene Name	chloride channel accessory 4
Protein Entry	CLCA4_HUMAN
UniProt ID	Q14CN2
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14CN2-1; Sequence=Displayed; Name=2; IsoId=Q14CN2-2; Sequence=VSP_056117, VSP_056118, VSP_056119; Note=No experimental confirmation available.;
Domain	The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA Substrates. {ECO:0000250\|UniProtKB:A8K7I4}.
Function	May be involved in mediating calcium-activated chloride conductance.
Induction	Down-regulated in oral tongue squamous cell carcinomas. {ECO:0000269\|PubMed:18254958}.
Ptm	The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N- terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium- activated chloride channel (CaCC) activation activity. {ECO:0000250\|UniProtKB:A8K7I4}.
Similarity	Belongs to the CLCR family. {ECO:0000305}.
Similarity	Contains 1 VWFA domain. {ECO:0000255\|PROSITE- ProRule:PRU00219}.
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}. Secreted {ECO:0000250}. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. {ECO:0000250}.
Tissue Specificity	Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp. {ECO:0000269\|PubMed:10437792, ECO:0000269\|PubMed:15490240, ECO:0000269\|PubMed:16012037}.