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MGP004525

UniProt Annotations

Entry Information
Gene NameRAB11 family interacting protein 2 (class I)
Protein EntryRFIP2_HUMAN
UniProt IDQ7L804
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L804-1; Sequence=Displayed; Name=2; IsoId=Q7L804-2; Sequence=VSP_056649;
FunctionA Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231}.
InteractionP62491:RAB11A; NbExp=2; IntAct=EBI-1049676, EBI-745098;
PtmPhosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity. {ECO:0000269|PubMed:16775013}.
Sequence CautionSequence=BAA76785.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 FIP-RBD domain. {ECO:0000255|PROSITE- ProRule:PRU00844}.
Subcellular LocationCell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
SubunitHomooligomerizes in a Rab11-independent manner. Forms a heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB25 and REPS1. Interacts with RAB11A and RAB11B (activated GTP-bound form). Interacts with NPC1L1. Interacts (via NPF motifs) with EHD1 and EHD3. {ECO:0000269|PubMed:11495908, ECO:0000269|PubMed:11944901, ECO:0000269|PubMed:11994279, ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:12470645, ECO:0000269|PubMed:15173169, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:19542231}.
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