MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004526

Record overview

MGPD IDMGP004526
Gene ID22845
SpeciesHomo sapiens (Human)
Gene Namedolichol kinase
Gene Symbol DOLK
SynonymsDK; DK1; CDG1M; SEC59; TMEM15;
Alternate namesdolichol kinase; SEC59 homolog; dolichol kinase 1; transmembrane protein 15;
Chromosome9
Map Location9q34.11
EC Number2.7.1.108
SummaryThe protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
OrthologsView orthologs and multiple alignments for DOLK

Proteins

dolichol kinase
Refseq ID:NP_055723
Protein GI:7662482
UniProt ID:Q9UPQ8
mRNA ID:NM_014908
Length:538
RefSeq Status:
MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASMVMPLLGLVMKERCQ
TAGNPFFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGG
ISFVLNQLIKRSLTLVESQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIRRNPLLWLLQFLFQTDTRIYL
LAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERD
SGPLILTHIYLLLGMSLPIWLIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLN
YSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA
 
  logo