MGP Database

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MGP004544

UniProt Annotations

Entry Information
Gene Namemethionine sulfoxide reductase B2
Protein EntryMSRB2_HUMAN
UniProt IDQ9Y3D2
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityL-methionine + oxidized thioredoxin = L- methionine R-oxide + reduced thioredoxin.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionMethionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. {ECO:0000269|PubMed:18424444}.
Sequence CautionSequence=AAD34126.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
SimilarityBelongs to the MsrB Met sulfoxide reductase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:18424444}.
Tissue SpecificityUbiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. {ECO:0000269|PubMed:10375640, ECO:0000269|PubMed:15914630}.
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