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MGP004547

Record overview

MGPD IDMGP004547
Gene ID22928
SpeciesHomo sapiens (Human)
Gene Nameselenophosphate synthetase 2
Gene Symbol SEPHS2
SynonymsSPS2; SPS2b;
Alternate namesselenide, water dikinase 2; selenium donor protein 2; selenophosphate synthase 2;
Chromosome16
Map Location16p11.2
EC Number2.7.9.3
SummaryThis gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. Genes encoding selenocysteine contain a stem-loop secondary structure in their 3' UTR called a selenocysteine insertion sequence (SECIS) element. The protein encoded by this gene contains a selenocysteine residue in its predicted active site. There is a pseudogene for this gene on chromosome 5. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for SEPHS2

Proteins

selenide, water dikinase 2
Refseq ID:NP_036380
Protein GI:15011844
UniProt ID:Q99611
mRNA ID:NM_012248
Length:448
RefSeq Status:
MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKGUGCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEA
GLPAGAGPSPTFPALGIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVSQSMSEEEREKVTPLMVKGFR
DAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIMPDSAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVSREEVELAYQEAMFNMATLNR
TAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRFGLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQ
AWIVGIVEKGNRTARIIDKPRVIEVLPRGATAAVLAPDSSNASSEPSS
 
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