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MGP004552

Record overview

MGPD IDMGP004552
Gene ID22948
SpeciesHomo sapiens (Human)
Gene Namechaperonin containing TCP1, subunit 5 (epsilon)
Gene Symbol CCT5
SynonymsCCTE; HEL-S-69; CCT-epsilon; TCP-1-epsilon;
Alternate namesT-complex protein 1 subunit epsilon; T-complex protein 1, epsilon subunit; epididymis secretory protein Li 69;
Chromosome5
Map Location5p15.2
SummaryThe protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2010]
OrthologsView orthologs and multiple alignments for CCT5

Proteins

T-complex protein 1 subunit epsilon
Refseq ID:NP_036205
Protein GI:24307939
UniProt ID:P48643
mRNA ID:NM_012073
Length:541
RefSeq Status:
MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDD
EIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADME
RRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA
ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKR
SLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTND
MKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
 
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