MGP Database

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MGP004555

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
Protein EntryARK73_HUMAN
UniProt IDO95154
SpeciesHuman
Comments
Comment typeDescription
FunctionCan reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:18416522}.
SimilarityBelongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|Ref.6}.
Tissue SpecificityExpressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. {ECO:0000269|PubMed:12879023, ECO:0000269|PubMed:18416522}.
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