MGP Database

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MGP004558

UniProt Annotations

Entry Information
Gene Namesynaptic vesicle glycoprotein 2C
Protein EntrySV2C_HUMAN
UniProt IDQ496J9
SpeciesHuman
Comments
Comment typeDescription
FunctionPlays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.
PtmN-glycosylated. {ECO:0000250}.
SimilarityBelongs to the major facilitator superfamily. {ECO:0000305}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). {ECO:0000250}.
SubunitInteracts with SYT1 in a calcium-dependent manner. {ECO:0000250}.
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