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MGP004563

UniProt Annotations

Entry Information
Gene Namedishevelled associated activator of morphogenesis 1
Protein EntryDAAM1_HUMAN
UniProt IDQ9Y4D1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y4D1-1; Sequence=Displayed; Name=2; IsoId=Q9Y4D1-2; Sequence=VSP_008000; Name=3; IsoId=Q9Y4D1-3; Sequence=VSP_008001, VSP_008002, VSP_008003;
DomainThe C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.
DomainThe DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity). {ECO:0000250}.
FunctionBinds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. {ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.
InteractionSelf; NbExp=2; IntAct=EBI-2817289, EBI-2817289; Q5T0N5:FNBP1L; NbExp=2; IntAct=EBI-2817289, EBI-714058; P61586:RHOA; NbExp=5; IntAct=EBI-2817289, EBI-446668; P00523:SRC (xeno); NbExp=3; IntAct=EBI-2817289, EBI-848039; Q15642-2:TRIP10; NbExp=2; IntAct=EBI-2817289, EBI-6550597;
Sequence CautionSequence=BAA31641.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04230.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the formin homology family. {ECO:0000305}.
SimilarityContains 1 DAD (diaphanous autoregulatory) domain. {ECO:0000255|PROSITE-ProRule:PRU00577}.
SimilarityContains 1 FH1 (formin homology 1) domain. {ECO:0000305}.
SimilarityContains 1 FH2 (formin homology 2) domain. {ECO:0000255|PROSITE-ProRule:PRU00774}.
SimilarityContains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. {ECO:0000255|PROSITE-ProRule:PRU00579}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16630611}. Note=Perinuclear.
SubunitHomodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA. {ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.
Tissue SpecificityExpressed in all tissues examined.
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