MGP Database

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MGP004586

UniProt Annotations

Entry Information
Gene NameRAP1 GTPase activating protein 2
Protein EntryRPGP2_HUMAN
UniProt IDQ684P5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Rap1GAP2b; IsoId=Q684P5-1; Sequence=Displayed; Name=2; Synonyms=Rap1GAP2a; IsoId=Q684P5-2; Sequence=VSP_029889; Name=3; Synonyms=Rap1GAP2c; IsoId=Q684P5-3; Sequence=VSP_029888;
FunctionGTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}.
PtmIn vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity. {ECO:0000269|PubMed:15632203, ECO:0000269|PubMed:16964243, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:21406692}.
SimilarityContains 1 Rap-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00165}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:15632203}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15632203}.
Tissue SpecificityIsoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas. {ECO:0000269|PubMed:15632203}.
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