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MGP004593

UniProt Annotations

Entry Information
Gene Nameplexin D1
Protein EntryPLXD1_HUMAN
UniProt IDQ9Y4D7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y4D7-1; Sequence=Displayed; Name=2; IsoId=Q9Y4D7-2; Sequence=VSP_011516;
FunctionCell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. {ECO:0000250, ECO:0000269|PubMed:20385769}.
InteractionP22736:NR4A1; NbExp=2; IntAct=EBI-310731, EBI-721550; O15041:SEMA3E; NbExp=2; IntAct=EBI-310731, EBI-7283693; P70275:Sema3e (xeno); NbExp=2; IntAct=EBI-310731, EBI-8876322; Q9H3S1:SEMA4A; NbExp=2; IntAct=EBI-310731, EBI-3924922;
Sequence CautionSequence=BAA31595.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the plexin family. {ECO:0000305}.
SimilarityContains 1 Sema domain. {ECO:0000255|PROSITE- ProRule:PRU00352}.
SimilarityContains 3 IPT/TIG domains. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
SubunitInteracts with NRP1, SEMA4A, SEMA3A, SEMA3C and SEMA3E. {ECO:0000250}.
Tissue SpecificityDetected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes. {ECO:0000269|PubMed:12412018}.
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