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MGP004599

UniProt Annotations

Entry Information
Gene Namestabilin 1
Protein EntrySTAB1_HUMAN
UniProt IDQ9NY15
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 {ECO:0000269|PubMed:12077138}; IsoId=Q9NY15-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:12077138}; IsoId=Q9NY15-2; Sequence=VSP_050764, VSP_050765;
FunctionActs as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:16357325}.
Sequence CautionSequence=BAA13377.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 16 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076, ECO:0000305}.
SimilarityContains 1 Link domain. {ECO:0000255|PROSITE- ProRule:PRU00323, ECO:0000305}.
SimilarityContains 2 laminin EGF-like domains. {ECO:0000305}.
SimilarityContains 7 FAS1 domains. {ECO:0000255|PROSITE- ProRule:PRU00082, ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
SubunitInteracts with CHID1. {ECO:0000269|PubMed:16357325}.
Tissue SpecificityHigh levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells. {ECO:0000269|PubMed:11829752, ECO:0000269|PubMed:12077138}.
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