MGP Database

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MGP004606

UniProt Annotations

Entry Information
Gene Nameglucosidase, alpha; neutral AB
Protein EntryGANAB_HUMAN
UniProt IDQ14697
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14697-1; Sequence=Displayed; Name=2; IsoId=Q14697-2; Sequence=VSP_010674; Name=3; IsoId=Q14697-3; Sequence=VSP_039976, VSP_039977; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
Catalytic ActivityHydrolysis of terminal (1->3)-alpha-D- glucosidic links in (1->3)-alpha-D-glucans.
FunctionCleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. {ECO:0000269|PubMed:10929008}.
InteractionP78545:ELF3; NbExp=1; IntAct=EBI-348004, EBI-1057285; P48634:PRRC2A; NbExp=1; IntAct=EBI-348004, EBI-347545; Q9Y4K3:TRAF6; NbExp=1; IntAct=EBI-348004, EBI-359276;
PathwayGlycan metabolism; N-glycan metabolism.
Sequence CautionSequence=AAH65266.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
SimilarityBelongs to the glycosyl hydrolase 31 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Melanosome {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitHeterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC (By similarity). {ECO:0000250}.
Tissue SpecificityDetected in placenta. {ECO:0000269|PubMed:3881423}.
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