MGP Database

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MGP004616

Ontology/Pathway Information

Entrez Gene ID23236
Gene Namephospholipase C, beta 1 (phosphoinositide-specific)
Gene Symbol PLCB1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0000790 ISS:BHF-UCLCnuclear chromatin
GO:0031965 IEA:UniProtKB-SubCellCnuclear membrane
GO:0016607 IDA:BHF-UCLCnuclear speck
GO:0005634 NAS:UniProtKBCnucleus
GO:0005509 IEA:InterProFcalcium ion binding
GO:0005516 IPI:BHF-UCLFcalmodulin binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0005096 IDA:BHF-UCLFGTPase activator activity
GO:0005546 IDA:BHF-UCLFphosphatidylinositol-4,5-bisphosphate binding
GO:0004435 NAS:UniProtKBFphosphatidylinositol phospholipase C activity
GO:0042803 ISS:BHF-UCLFprotein homodimerization activity
GO:0004871 IEA:UniProtKB-KWFsignal transducer activity
GO:0060466 ISS:BHF-UCLPactivation of meiosis involved in egg activation
GO:0021987 ISS:BHF-UCLPcerebral cortex development
GO:0045444 IEA:EnsemblPfat cell differentiation
GO:0000086 ISS:BHF-UCLPG2/M transition of mitotic cell cycle
GO:0007215 ISS:BHF-UCLPglutamate receptor signaling pathway
GO:0007213 ISS:BHF-UCLPG-protein coupled acetylcholine receptor signaling pathway
GO:0043647 TAS:ReactomePinositol phosphate metabolic process
GO:0048009 ISS:BHF-UCLPinsulin-like growth factor receptor signaling pathway
GO:0035722 IDA:BHF-UCLPinterleukin-12-mediated signaling pathway
GO:0035723 IDA:BHF-UCLPinterleukin-15-mediated signaling pathway
GO:0070498 IDA:BHF-UCLPinterleukin-1-mediated signaling pathway
GO:0035556 IEA:InterProPintracellular signal transduction
GO:0016042 IEA:UniProtKB-KWPlipid catabolic process
GO:0007613 ISS:BHF-UCLPmemory
GO:2000438 ISS:BHF-UCLPnegative regulation of monocyte extravasation
GO:0045892 ISS:BHF-UCLPnegative regulation of transcription, DNA-templated
GO:0046488 ISS:BHF-UCLPphosphatidylinositol metabolic process
GO:2000344 ISS:BHF-UCLPpositive regulation of acrosome reaction
GO:2000560 ISS:BHF-UCLPpositive regulation of CD24 biosynthetic process
GO:0048639 ISS:BHF-UCLPpositive regulation of developmental growth
GO:0040019 ISS:BHF-UCLPpositive regulation of embryonic development
GO:1900087 ISS:BHF-UCLPpositive regulation of G1/S transition of mitotic cell cycle
GO:0043547 IDA:GOCPpositive regulation of GTPase activity
GO:0032735 ISS:BHF-UCLPpositive regulation of interleukin-12 production
GO:0046330 IDA:BHF-UCLPpositive regulation of JNK cascade
GO:0045663 ISS:BHF-UCLPpositive regulation of myoblast differentiation
GO:0045893 ISS:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0080154 ISS:BHF-UCLPregulation of fertilization
GO:0008277 ISS:BHF-UCLPregulation of G-protein coupled receptor protein signaling pathway
GO:0007165 NAS:UniProtKBPsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007268 TAS:ReactomePsynaptic transmission
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18405Acetylcholine regulates insulin secretion
REACT_21312Activation of Kainate Receptors upon glutamate binding
REACT_264224beta-catenin independent WNT signaling
REACT_263982Ca2+ pathway
REACT_19193Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
REACT_19375Free fatty acids regulate insulin secretion
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19145G beta:gamma signalling through PLC beta
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_15526G-protein mediated events
REACT_150154Inositol phosphate metabolism
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15295Opioid Signalling
REACT_15426PLC beta mediated events
REACT_21254Presynaptic function of Kainate receptors
REACT_18325Regulation of insulin secretion
REACT_14797Signaling by GPCR
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_150312Synthesis of IP3 and IP4 in the cytosol
REACT_13477Transmission across Chemical Synapses
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00582Joubert syndrome
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00463Phosphatidylinositol Phosphate Metabolism
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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