MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004640

UniProt Annotations

Entry Information
Gene Namejade family PHD finger 2
Protein EntryJADE2_HUMAN
UniProt IDQ9NQC1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NQC1-1; Sequence=Displayed; Name=2; IsoId=Q9NQC1-2; Sequence=VSP_021051; Name=3; IsoId=Q9NQC1-3; Sequence=VSP_021050; Note=No experimental confirmation available.;
FunctionComponent of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. {ECO:0000269|PubMed:16387653}.
Sequence CautionSequence=BAA13245.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84949.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305}; Sequence=CAB94935.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the JADE family. {ECO:0000305}.
SimilarityContains 1 PHD-type zinc finger. {ECO:0000255|PROSITE- ProRule:PRU00146}.
SubunitComponent of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. {ECO:0000269|PubMed:16387653}.
  logo