MGP Database

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MGP004642

UniProt Annotations

Entry Information
Gene Namededicator of cytokinesis 9
Protein EntryDOCK9_HUMAN
UniProt IDQ9BZ29
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9BZ29-1; Sequence=Displayed; Name=2; IsoId=Q9BZ29-5; Sequence=VSP_017128; Name=3; IsoId=Q9BZ29-3; Sequence=VSP_004024; Note=No experimental confirmation available.; Name=4; IsoId=Q9BZ29-4; Sequence=VSP_007709, VSP_007710; Note=Produced by exon skipping that results in a frameshift. No experimental confirmation available.; Name=5; IsoId=Q9BZ29-6; Sequence=VSP_017128, VSP_045683, VSP_045684; Note=No experimental confirmation available.;
DomainThe DHR-2 domain is necessary and sufficient for the GEF activity.
FunctionGuanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}.
InteractionP20929:NEB; NbExp=2; IntAct=EBI-2695893, EBI-1049657; Q15796:SMAD2; NbExp=3; IntAct=EBI-2695893, EBI-1040141; P84022:SMAD3; NbExp=3; IntAct=EBI-2695893, EBI-347161;
Miscellaneous'Zizim' means 'spike' in Hebrew.
Sequence CautionSequence=BAA83010.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the DOCK family. {ECO:0000305}.
SimilarityContains 1 DHR-1 domain. {ECO:0000305}.
SimilarityContains 1 DHR-2 domain. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationEndomembrane system {ECO:0000305}. Note=Associated with membranes. {ECO:0000305}.
SubunitHomodimer (Probable). Interacts preferentially with nucleotide-depleted CDC42. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154, ECO:0000305}.
Tissue SpecificityWidely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle. {ECO:0000269|PubMed:12172552}.
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