MGP Database

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MGP004645

Ontology/Pathway Information

Entrez Gene ID23365
Gene NameRho guanine nucleotide exchange factor (GEF) 12
Gene Symbol ARHGEF12
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:MGICcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 IEA:UniProtKB-SubCellCmembrane
GO:0001664 IDA:MGIFG-protein coupled receptor binding
GO:0005096 IEA:UniProtKB-KWFGTPase activator activity
GO:0005089 IEA:InterProFRho guanyl-nucleotide exchange factor activity
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0007411 TAS:ReactomePaxon guidance
GO:0007186 IDA:MGIPG-protein coupled receptor signaling pathway
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0051056 TAS:ReactomePregulation of small GTPase mediated signal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0038032 IEA:InterProPtermination of G-protein coupled receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18266Axon guidance
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_111045Developmental Biology
REACT_18407G alpha (12/13) signalling events
REACT_19184GPCR downstream signaling
REACT_13638NRAGE signals death through JNK
REACT_13776p75 NTR receptor-mediated signalling
REACT_11051Rho GTPase cycle
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19259Sema4D in semaphorin signaling
REACT_19271Semaphorin interactions
REACT_14797Signaling by GPCR
REACT_11044Signaling by Rho GTPases
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
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