MGP Database

MGP004661

Ontology/Pathway Information

Entrez Gene ID23411
Gene Namesirtuin 1
Gene Symbol SIRT1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005677 IDA:UniProtKBCchromatin silencing complex
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005739 IDA:HPACmitochondrion
GO:0000790 IDA:UniProtKBCnuclear chromatin
GO:0005635 IDA:BHF-UCLCnuclear envelope
GO:0005719 IDA:UniProtKBCnuclear euchromatin
GO:0005720 IDA:UniProtKBCnuclear heterochromatin
GO:0005637 IDA:UniProtKBCnuclear inner membrane
GO:0005730 IDA:BHF-UCLCnucleolus
GO:0005654 IDA:UniProtKBCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0016605 IDA:BHF-UCLCPML body
GO:0033553 IDA:UniProtKBCrDNA heterochromatin
GO:0043425 IPI:UniProtKBFbHLH transcription factor binding
GO:0019213 IDA:UniProtKBFdeacetylase activity
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0042393 IPI:UniProtKBFhistone binding
GO:0004407 IDA:BHF-UCLFhistone deacetylase activity
GO:0043398 IPI:BHF-UCLFHLH domain binding
GO:0042802 IPI:BHF-UCLFidentical protein binding
GO:1990254 IPI:UniProtKBFkeratin filament binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0051019 IPI:BHF-UCLFmitogen-activated protein kinase binding
GO:0070403 IEA:InterProFNAD+ binding
GO:0017136 IDA:BHF-UCLFNAD-dependent histone deacetylase activity
GO:0046969 ISS:UniProtKBFNAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0034979 IDA:UniProtKBFNAD-dependent protein deacetylase activity
GO:0002039 IPI:BHF-UCLFp53 binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0033558 IDA:UniProtKBFprotein deacetylase activity
GO:0003714 IDA:BHF-UCLFtranscription corepressor activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0001525 IDA:UniProtKBPangiogenesis
GO:0007569 TAS:BHF-UCLPcell aging
GO:0001678 ISS:UniProtKBPcellular glucose homeostasis
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:0070301 IDA:BHF-UCLPcellular response to hydrogen peroxide
GO:0071456 IMP:UniProtKBPcellular response to hypoxia
GO:0071479 ISS:UniProtKBPcellular response to ionizing radiation
GO:0009267 ISS:BHF-UCLPcellular response to starvation
GO:0071356 IDA:UniProtKBPcellular response to tumor necrosis factor
GO:0035356 ISS:UniProtKBPcellular triglyceride homeostasis
GO:0042632 ISS:UniProtKBPcholesterol homeostasis
GO:0006325 IMP:UniProtKBPchromatin organization
GO:0006342 TAS:ProtIncPchromatin silencing
GO:0000183 IDA:UniProtKBPchromatin silencing at rDNA
GO:0032922 IMP:UniProtKBPcircadian regulation of gene expression
GO:0006281 TAS:BHF-UCLPDNA repair
GO:0006260 TAS:BHF-UCLPDNA replication
GO:0000731 ISS:UniProtKBPDNA synthesis involved in DNA repair
GO:0006343 IDA:BHF-UCLPestablishment of chromatin silencing
GO:0055089 ISS:UniProtKBPfatty acid homeostasis
GO:0016575 IDA:UniProtKBPhistone deacetylation
GO:0070932 IDA:BHF-UCLPhistone H3 deacetylation
GO:0061647 ISS:GOCPhistone H3-K9 modification
GO:0042771 IMP:UniProtKBPintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0006344 IMP:BHF-UCLPmaintenance of chromatin silencing
GO:0006346 TAS:UniProtKBPmethylation-dependent chromatin silencing
GO:0007517 IEA:UniProtKB-KWPmuscle organ development
GO:0060766 IMP:BHF-UCLPnegative regulation of androgen receptor signaling pathway
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:2000480 IDA:UniProtKBPnegative regulation of cAMP-dependent protein kinase activity
GO:0030308 IMP:BHF-UCLPnegative regulation of cell growth
GO:2000655 IMP:BHF-UCLPnegative regulation of cellular response to testosterone stimulus
GO:2000773 IDA:UniProtKBPnegative regulation of cellular senescence
GO:0043518 IDA:BHF-UCLPnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045599 ISS:BHF-UCLPnegative regulation of fat cell differentiation
GO:0051097 IDA:UniProtKBPnegative regulation of helicase activity
GO:0043124 IDA:UniProtKBPnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902166 ISS:BHF-UCLPnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1901215 IEA:EnsemblPnegative regulation of neuron death
GO:0032088 IDA:UniProtKBPnegative regulation of NF-kappaB transcription factor activity
GO:1902176 IMP:BHF-UCLPnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000757 IDA:UniProtKBPnegative regulation of peptidyl-lysine acetylation
GO:0042326 IMP:UniProtKBPnegative regulation of phosphorylation
GO:0031393 ISS:UniProtKBPnegative regulation of prostaglandin biosynthetic process
GO:0051898 IMP:UniProtKBPnegative regulation of protein kinase B signaling
GO:0043433 IDA:BHF-UCLPnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0032007 IMP:UniProtKBPnegative regulation of TOR signaling
GO:0045892 IDA:BHF-UCLPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0030512 ISS:UniProtKBPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0001542 IEA:EnsemblPovulation from ovarian follicle
GO:0018394 IMP:UniProtKBPpeptidyl-lysine acetylation
GO:0034983 IDA:BHF-UCLPpeptidyl-lysine deacetylation
GO:0002821 IDA:UniProtKBPpositive regulation of adaptive immune response
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:2000481 IMP:UniProtKBPpositive regulation of cAMP-dependent protein kinase activity
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:2000774 IDA:UniProtKBPpositive regulation of cellular senescence
GO:0010875 ISS:UniProtKBPpositive regulation of cholesterol efflux
GO:0031937 IMP:BHF-UCLPpositive regulation of chromatin silencing
GO:0043280 IMP:UniProtKBPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045739 IMP:UniProtKBPpositive regulation of DNA repair
GO:0051574 IMP:UniProtKBPpositive regulation of histone H3-K9 methylation
GO:0046628 IDA:UniProtKBPpositive regulation of insulin receptor signaling pathway
GO:0016239 IDA:UniProtKBPpositive regulation of macroautophagy
GO:2000111 ISS:UniProtKBPpositive regulation of macrophage apoptotic process
GO:0045348 IDA:UniProtKBPpositive regulation of MHC class II biosynthetic process
GO:0001934 ISS:UniProtKBPpositive regulation of protein phosphorylation
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0043161 IMP:UniProtKBPproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006476 IDA:UniProtKBPprotein deacetylation
GO:0031648 ISS:UniProtKBPprotein destabilization
GO:0016567 IDA:UniProtKBPprotein ubiquitination
GO:0000720 IMP:UniProtKBPpyrimidine dimer repair by nucleotide-excision repair
GO:0070857 ISS:UniProtKBPregulation of bile acid biosynthetic process
GO:0042127 IMP:BHF-UCLPregulation of cell proliferation
GO:0032071 IMP:UniProtKBPregulation of endodeoxyribonuclease activity
GO:0010906 ISS:UniProtKBPregulation of glucose metabolic process
GO:0007346 IDA:UniProtKBPregulation of mitotic cell cycle
GO:0035358 ISS:BHF-UCLPregulation of peroxisome proliferator activated receptor signaling pathway
GO:0033158 IMP:UniProtKBPregulation of protein import into nucleus, translocation
GO:0034391 ISS:UniProtKBPregulation of smooth muscle cell apoptotic process
GO:0034976 ISS:UniProtKBPresponse to endoplasmic reticulum stress
GO:0042542 IDA:UniProtKBPresponse to hydrogen peroxide
GO:0032868 ISS:UniProtKBPresponse to insulin
GO:0006979 IDA:UniProtKBPresponse to oxidative stress
GO:0006364 IEA:UniProtKB-KWPrRNA processing
GO:0000012 IMP:UniProtKBPsingle strand break repair
GO:0007283 IEA:EnsemblPspermatogenesis
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0006642 ISS:BHF-UCLPtriglyceride mobilization
GO:0016032 IEA:UniProtKB-KWPviral process
GO:0050872 ISS:BHF-UCLPwhite fat cell differentiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120956Cellular responses to stress
REACT_263897Cellular response to heat stress
REACT_264098Epigenetic regulation of gene expression
REACT_71Gene Expression
REACT_264000Negative epigenetic regulation of rRNA expression
REACT_264487Regulation of HSF1-mediated heat shock response
REACT_264541SIRT1 negatively regulates rRNA Expression
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