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MGP004664

UniProt Annotations

Entry Information
Gene Namepotassium channel, voltage gated eag related subfamily H, member 3
Protein EntryKCNH3_HUMAN
UniProt IDQ9ULD8
SpeciesHuman
Comments
Comment typeDescription
DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
FunctionPore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
InteractionP04578:env (xeno); NbExp=3; IntAct=EBI-8079227, EBI-6163496;
Sequence CautionSequence=BAA86596.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. {ECO:0000305}.
SimilarityContains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00060}.
SimilarityContains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule:PRU00141}.
SimilarityContains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule:PRU00140}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitThe potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Tissue SpecificityDetected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.
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