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MGP004667

UniProt Annotations

Entry Information
Gene Nameglutamate receptor interacting protein 1
Protein EntryGRIP1_HUMAN
UniProt IDQ9Y3R0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y3R0-1; Sequence=Displayed; Name=2; IsoId=Q9Y3R0-2; Sequence=VSP_009743; Note=No experimental confirmation available.; Name=3; IsoId=Q9Y3R0-3; Sequence=VSP_040281;
DiseaseFraser syndrome (FRASS) [MIM:219000]: Multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects. {ECO:0000269|PubMed:22510445}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
DomainPDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins- alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ- binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR. {ECO:0000250}.
FunctionMay play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. {ECO:0000269|PubMed:10197531}.
InteractionP03372:ESR1; NbExp=2; IntAct=EBI-5349621, EBI-78473; Q14653:IRF3; NbExp=2; IntAct=EBI-5349621, EBI-2650369; P49683:PRLHR; NbExp=2; IntAct=EBI-5349621, EBI-8009236; P28065:PSMB9; NbExp=3; IntAct=EBI-5349621, EBI-603300;
SimilarityContains 7 PDZ (DHR) domains. {ECO:0000255|PROSITE- ProRule:PRU00143}.
Subcellular LocationCytoplasmic vesicle {ECO:0000269|PubMed:10197531}. Endoplasmic reticulum {ECO:0000269|PubMed:10197531}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity). {ECO:0000250}.
SubunitInteracts with EPHA7, EPHB2, KIF5A, KIF5B, KIF5C, GRIA2, GRIA3, GRIPAP1/GRASP1, PPFIA1, PPFIA4, FRAS1, PLCD4, PTPRF and liprins-alpha. Can form homomultimers or heteromultimers with GRIP2. Forms a ternary complex with GRIA2 and CSPG4 (By similarity). Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIA2 and leads to AMPAR complex disassembly (By similarity). Interacts with EFNB1, EFNB3 and the C-terminal tail of PRLHR. Interacts with SLC30A9 (By similarity). Interacts with WBSCR22. {ECO:0000250, ECO:0000269|PubMed:10197531, ECO:0000269|PubMed:11641419, ECO:0000269|PubMed:24488492}.
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