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MGP004694

UniProt Annotations

Entry Information
Gene Namesolute carrier family 39 (zinc transporter), member 14
Protein EntryS39AE_HUMAN
UniProt IDQ15043
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15043-1; Sequence=Displayed; Name=2; IsoId=Q15043-2; Sequence=VSP_029728; Note=No experimental confirmation available.; Name=3; IsoId=Q15043-3; Sequence=VSP_040139;
FunctionMay mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake. {ECO:0000250, ECO:0000269|PubMed:15642354}.
Sequence CautionSequence=BAA06685.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the ZIP transporter (TC 2.A.5) family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, lamellipodium {ECO:0000269|PubMed:12659941, ECO:0000269|PubMed:15642354}. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.
SubunitHomotrimer. {ECO:0000269|PubMed:12659941}.
Tissue SpecificityUbiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes. {ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:7584044}.
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