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MGP004711

UniProt Annotations

Entry Information
Gene Nameelongator acetyltransferase complex subunit 5
Protein EntryELP5_HUMAN
UniProt IDQ8TE02
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8TE02-1; Sequence=Displayed; Name=2; IsoId=Q8TE02-2; Sequence=VSP_023923; Note=Ref.8 (AAQ13591) sequence is in conflict in position: 263:H->Q. {ECO:0000305}; Name=3; IsoId=Q8TE02-3; Sequence=VSP_023920, VSP_023921; Name=4; IsoId=Q8TE02-4; Sequence=VSP_023922;
CautionIt is uncertain whether Met-1 or Met-17 is the initiator. {ECO:0000305}.
FunctionActs as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation. {ECO:0000250, ECO:0000269|PubMed:16850183}.
InteractionP54253:ATXN1; NbExp=2; IntAct=EBI-946189, EBI-930964; Q96EB1:ELP4; NbExp=4; IntAct=EBI-946189, EBI-3951755;
Sequence CautionSequence=AAD20964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13591.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the ELP5 family. {ECO:0000305}.
Subcellular LocationNucleus. Cytoplasm.
SubunitComponent of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for optimal binding of ELP3 to ELP4. {ECO:0000269|PubMed:22854966}.
Tissue SpecificityUbiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.
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