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MGP004723

Record overview

MGPD IDMGP004723
Gene ID23620
SpeciesHomo sapiens (Human)
Gene Nameneurotensin receptor 2
Gene Symbol NTSR2
SynonymsNTR2;
Alternate namesneurotensin receptor type 2; NT-R-2; levocabastine-sensitive neurotensin receptor; neurotensin receptor, type 2;
Chromosome2
Map Location2p25.1
SummaryThe protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for NTSR2

Proteins

neurotensin receptor type 2
Refseq ID:NP_036476
Protein GI:6912538
UniProt ID:O95665
mRNA ID:NM_012344
Length:410
RefSeq Status:
METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYP
WVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSR
TALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLR
AIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTAS
GFGDPPETRT
 
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