MGP Database

MGP004727

Record overview

MGPD ID	MGP004727
Gene ID	23643
Species	Homo sapiens (Human)
Gene Name	lymphocyte antigen 96
Gene Symbol	LY96
Synonyms	MD2; MD-2; ly-96; ESOP-1;
Alternate names	lymphocyte antigen 96; myeloid differentiation protein-2; protein MD-2;
Chromosome	8
Map Location	8q21.11
Summary	This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
Orthologs	View orthologs and multiple alignments for LY96

Proteins

lymphocyte antigen 96 isoform 1 precursor

Refseq ID:	NP_056179
Protein GI:	307775407
UniProt ID:	Q9Y6Y9
mRNA ID:	NM_015364
Length:	160
RefSeq Status:

`MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKGSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDD DYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN`

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2098
peptide sequence: 
MLPFLFFSTLFSSIFTEA

mat_peptide: 19..130
product: lymphocyte antigen 96 isoform 2
calculated_mol_wt: 12853
peptide sequence: 
QKQYWVCNSSDASISYTYCGRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFC
LEFVILHQPNSN

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2098
peptide sequence: 
MLPFLFFSTLFSSIFTEA

mat_peptide: 19..160
product: lymphocyte antigen 96 isoform 1
calculated_mol_wt: 16366
peptide sequence: 
QKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKGSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTIS
FSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN

lymphocyte antigen 96 isoform 2 precursor

Refseq ID:	NP_001182726
Protein GI:	307775409
UniProt ID:	Q9Y6Y9
mRNA ID:	NM_001195797
Length:	130
RefSeq Status:

`MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCGRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGK YKCVVEAISGSPEEMLFCLEFVILHQPNSN`

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2098
peptide sequence: 
MLPFLFFSTLFSSIFTEA

mat_peptide: 19..130
product: lymphocyte antigen 96 isoform 2
calculated_mol_wt: 12853
peptide sequence: 
QKQYWVCNSSDASISYTYCGRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFC
LEFVILHQPNSN