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MGP004729

Ontology/Pathway Information

Entrez Gene ID23645
Gene Nameprotein phosphatase 1, regulatory subunit 15A
Gene Symbol PPP1R15A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:ParkinsonsUK-UCLCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005783 IDA:ParkinsonsUK-UCLCendoplasmic reticulum
GO:0005789 NAS:ParkinsonsUK-UCLCendoplasmic reticulum membrane
GO:0005794 IDA:ParkinsonsUK-UCLCGolgi apparatus
GO:0016020 IDA:ParkinsonsUK-UCLCmembrane
GO:0005741 IEA:UniProtKB-SubCellCmitochondrial outer membrane
GO:0005739 IDA:ParkinsonsUK-UCLCmitochondrion
GO:0000164 IDA:ParkinsonsUK-UCLCprotein phosphatase type 1 complex
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0008157 IDA:ParkinsonsUK-UCLFprotein phosphatase 1 binding
GO:0071862 IC:ParkinsonsUK-UCLFprotein phosphatase type 1 activator activity
GO:0008599 IC:ParkinsonsUK-UCLFprotein phosphatase type 1 regulator activity
GO:0006915 TAS:ProtIncPapoptotic process
GO:0007050 TAS:ProtIncPcell cycle arrest
GO:0006974 TAS:ProtIncPcellular response to DNA damage stimulus
GO:0030968 IEA:EnsemblPendoplasmic reticulum unfolded protein response
GO:0032515 IDA:ParkinsonsUK-UCLPnegative regulation of phosphoprotein phosphatase activity
GO:0035308 IDA:ParkinsonsUK-UCLPnegative regulation of protein dephosphorylation
GO:0030512 TAS:ReactomePnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0010628 IMP:ParkinsonsUK-UCLPpositive regulation of gene expression
GO:1902310 IDA:ParkinsonsUK-UCLPpositive regulation of peptidyl-serine dephosphorylation
GO:0033138 IMP:ParkinsonsUK-UCLPpositive regulation of peptidyl-serine phosphorylation
GO:0032516 IDA:ParkinsonsUK-UCLPpositive regulation of phosphoprotein phosphatase activity
GO:0045943 IGI:ParkinsonsUK-UCLPpositive regulation of transcription from RNA polymerase I promoter
GO:0032058 IC:ParkinsonsUK-UCLPpositive regulation of translational initiation in response to stress
GO:0070972 IMP:ParkinsonsUK-UCLPprotein localization to endoplasmic reticulum
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
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