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MGP004730

Record overview

MGPD IDMGP004730
Gene ID23646
SpeciesHomo sapiens (Human)
Gene Namephospholipase D family, member 3
Gene Symbol PLD3
SynonymsAD19; HUK4; HU-K4;
Alternate namesphospholipase D3; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydrolyzing phospholipase D3;
Chromosome19
Map Location19q13.2
EC Number3.1.4.4
SummaryThis gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
OrthologsView orthologs and multiple alignments for PLD3

Proteins

phospholipase D3
Refseq ID:NP_036400
Protein GI:166197683
UniProt ID:Q8IV08
mRNA ID:NM_012268
Length:490
RefSeq Status:
MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNAST
GNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVL
HTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLC
PSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVV
PADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL
 
phospholipase D3
Refseq ID:NP_001278240
Protein GI:605052028
UniProt ID:Q8IV08
mRNA ID:NM_001291311
Length:490
RefSeq Status:
Protein sequence is identical to GI:166197683 (mRNA isoform)
 
phospholipase D3
Refseq ID:NP_001026866
Protein GI:72534684
UniProt ID:Q8IV08
mRNA ID:NM_001031696
Length:490
RefSeq Status:
Protein sequence is identical to GI:166197683 (mRNA isoform)
 
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