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MGP004737

UniProt Annotations

Entry Information
Gene Namecell adhesion molecule 1
Protein EntryCADM1_HUMAN
UniProt IDQ9BY67
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1 {ECO:0000269|PubMed:15893517}; IsoId=Q9BY67-1; Sequence=Displayed; Name=2 {ECO:0000269|Ref.4}; IsoId=Q9BY67-2; Sequence=VSP_052461, VSP_052462; Name=3; IsoId=Q9BY67-3; Sequence=VSP_047406; Name=4; IsoId=Q9BY67-4; Sequence=VSP_047407; Name=5; Synonyms=E; IsoId=Q9BY67-5; Sequence=VSP_047405;
DomainThe cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC. {ECO:0000269|PubMed:14633730, ECO:0000269|PubMed:15184878}.
FunctionMediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. {ECO:0000250, ECO:0000269|PubMed:11279526, ECO:0000269|PubMed:12050160, ECO:0000269|PubMed:12234973, ECO:0000269|PubMed:12920246, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:15905536, ECO:0000269|PubMed:22438059}.
PtmGlycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction. {ECO:0000250}.
Sequence CautionSequence=AAI25103.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305};
SimilarityBelongs to the nectin family. {ECO:0000305}.
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000255}.
SimilarityContains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000255}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:11279526}; Single-pass type I membrane protein {ECO:0000269|PubMed:11279526}. Cell junction, synapse {ECO:0000250}. Note=Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000250|UniProtKB:Q8R5M8, ECO:0000255, ECO:0000269|PubMed:11279526}.
SubunitHomodimer. Interacts with FARP1 (By similarity). Interacts with CRTAM. Interacts (via C-terminus) with EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6. {ECO:0000250, ECO:0000269|PubMed:12050160, ECO:0000269|PubMed:12234973, ECO:0000269|PubMed:13679854, ECO:0000269|PubMed:15781451, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:21131357}.
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