MGP Database

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MGP004738

UniProt Annotations

Entry Information
Gene NameG1 to S phase transition 2
Protein EntryERF3B_HUMAN
UniProt IDQ8IYD1
SpeciesHuman
Comments
Comment typeDescription
FunctionInvolved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. {ECO:0000269|PubMed:11524954, ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:17562865}.
InteractionP11940:PABPC1; NbExp=7; IntAct=EBI-3869637, EBI-81531; Q92900:UPF1; NbExp=3; IntAct=EBI-3869637, EBI-373471;
SimilarityBelongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
SimilarityContains 1 tr-type G (guanine nucleotide-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU01059}.
Subcellular LocationCytoplasm {ECO:0000305}.
SubunitInteracts with ETF1 (By similarity). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with UPF1 and PABPC1. {ECO:0000250, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104}.
Tissue SpecificityHighly expressed in IUCC stage II colorectal cancer (CRC). {ECO:0000269|PubMed:16721809}.
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