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MGP004758

UniProt Annotations

Entry Information
Gene Namesolute carrier family 39 (zinc transporter), member 6
Protein EntryS39A6_HUMAN
UniProt IDQ13433
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13433-1; Sequence=Displayed; Name=2; IsoId=Q13433-2; Sequence=VSP_014309, VSP_014310, VSP_014311; Note=No experimental confirmation available.;
FunctionMay act as a zinc-influx transporter. {ECO:0000269|PubMed:12839489}.
InductionUp-regulated by estrogen in breast cancer cells lines. {ECO:0000269|PubMed:2903103}.
PtmN-glycosylated. {ECO:0000269|PubMed:12839489, ECO:0000269|PubMed:19349973}.
Sequence CautionSequence=BAG61161.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the ZIP transporter (TC 2.A.5) family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:12839489}; Multi-pass membrane protein {ECO:0000269|PubMed:12839489}.
Tissue SpecificityHighly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. {ECO:0000269|PubMed:12839489}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SLC39A6ID44189ch18q12.html";
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