MGP Database

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MGP004784

Ontology/Pathway Information

Entrez Gene ID25937
Gene NameWW domain containing transcription regulator 1
Gene Symbol WWTR1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005667 IEA:EnsemblCtranscription factor complex
GO:0003713 IDA:UniProtKBFtranscription coactivator activity
GO:0003714 IEA:EnsemblFtranscription corepressor activity
GO:0060271 IEA:EnsemblPcilium morphogenesis
GO:0010467 TAS:ReactomePgene expression
GO:0032835 IEA:EnsemblPglomerulus development
GO:0035329 IDA:UniProtKBPhippo signaling
GO:0090090 IMP:BHF-UCLPnegative regulation of canonical Wnt signaling pathway
GO:0035414 IMP:BHF-UCLPnegative regulation of catenin import into nucleus
GO:0045599 IEA:EnsemblPnegative regulation of fat cell differentiation
GO:0006469 IMP:BHF-UCLPnegative regulation of protein kinase activity
GO:0001933 IMP:BHF-UCLPnegative regulation of protein phosphorylation
GO:0000122 IEA:EnsemblPnegative regulation of transcription from RNA polymerase II promoter
GO:0001649 IEA:EnsemblPosteoblast differentiation
GO:0008284 IDA:UniProtKBPpositive regulation of cell proliferation
GO:0010718 IDA:UniProtKBPpositive regulation of epithelial to mesenchymal transition
GO:0045944 TAS:ReactomePpositive regulation of transcription from RNA polymerase II promoter
GO:0072307 IEA:EnsemblPregulation of metanephric nephron tubule epithelial cell differentiation
GO:0060390 IDA:UniProtKBPregulation of SMAD protein import into nucleus
GO:0006355 NAS:UniProtKBPregulation of transcription, DNA-templated
GO:0017145 IDA:UniProtKBPstem cell division
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_118607Signaling by Hippo
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_118713YAP1- and WWTR1 (TAZ)-stimulated gene expression
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