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MGP004797

UniProt Annotations

Entry Information
Gene Nameleucine-rich repeats and immunoglobulin-like domains 1
Protein EntryLRIG1_HUMAN
UniProt IDQ96JA1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96JA1-1; Sequence=Displayed; Name=2; IsoId=Q96JA1-2; Sequence=VSP_011730, VSP_011731;
DomainThe LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted.
FunctionActs as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}.
InductionBy EGF. {ECO:0000269|PubMed:15282549}.
SimilarityContains 15 LRR (leucine-rich) repeats. {ECO:0000305}.
SimilarityContains 1 LRRCT domain. {ECO:0000305}.
SimilarityContains 1 LRRNT domain. {ECO:0000305}.
SimilarityContains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000269|PubMed:11414704}; Single-pass type I membrane protein {ECO:0000269|PubMed:11414704}.
SubunitInteracts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4. {ECO:0000269|PubMed:15282549}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:11414704}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LRIG1ID41198ch3p14.html";
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