MGP Database

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MGP004807

UniProt Annotations

Entry Information
Gene NameWD repeat and SOCS box containing 1
Protein EntryWSB1_HUMAN
UniProt IDQ9Y6I7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y6I7-1; Sequence=Displayed; Name=2; IsoId=Q9Y6I7-2; Sequence=VSP_006792; Name=3; IsoId=Q9Y6I7-3; Sequence=VSP_039111, VSP_039112; Name=4; IsoId=Q9Y6I7-4; Sequence=VSP_053402, VSP_053403;
DomainThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. {ECO:0000250}.
FunctionProbable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:15965468, ECO:0000269|PubMed:18093972}.
InteractionQ9QZR5:Hipk2 (xeno); NbExp=5; IntAct=EBI-1171494, EBI-366905;
PathwayProtein modification; protein ubiquitination.
SimilarityContains 1 SOCS box domain. {ECO:0000255|PROSITE- ProRule:PRU00194}.
SimilarityContains 6 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
SubunitInteracts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex which contains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Binds to HIPK2 through WD40 repeats. {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:15965468, ECO:0000269|PubMed:18093972}.
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