MGP Database

MGP004825

Ontology/Pathway Information

Entrez Gene ID	26227
Gene Name	phosphoglycerate dehydrogenase
Gene Symbol	PHGDH
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0009055	TAS:UniProtKB	F	electron carrier activity
GO:0051287	IEA:InterPro	F	NAD binding
GO:0004617	TAS:Reactome	F	phosphoglycerate dehydrogenase activity
GO:0007420	TAS:ProtInc	P	brain development
GO:0008652	TAS:Reactome	P	cellular amino acid biosynthetic process
GO:0034641	TAS:Reactome	P	cellular nitrogen compound metabolic process
GO:0070314	IEA:Ensembl	P	G1 to G0 transition
GO:0009448	IEA:Ensembl	P	gamma-aminobutyric acid metabolic process
GO:0021782	IEA:Ensembl	P	glial cell development
GO:0006541	IEA:Ensembl	P	glutamine metabolic process
GO:0006544	IEA:Ensembl	P	glycine metabolic process
GO:0006564	TAS:Reactome	P	L-serine biosynthetic process
GO:0021915	IEA:Ensembl	P	neural tube development
GO:0031175	IEA:Ensembl	P	neuron projection development
GO:0010468	IEA:Ensembl	P	regulation of gene expression
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0021510	IEA:Ensembl	P	spinal cord development
GO:0019530	IEA:Ensembl	P	taurine metabolic process
GO:0006566	IEA:Ensembl	P	threonine metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_238	Amino acid synthesis and interconversion (transamination)
REACT_111217	Metabolism
REACT_13	Metabolism of amino acids and derivatives
REACT_115789	Serine biosynthesis

SMP Pathway Links

SMP ID	Description
SMP00721	3-Phosphoglycerate dehydrogenase deficiency
SMP00179	Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
SMP00242	Dimethylglycine Dehydrogenase Deficiency
SMP00484	Dimethylglycinuria
SMP00004	Glycine and Serine Metabolism
SMP00485	Hyperglycinemia, non-ketotic
SMP00223	Non Ketotic Hyperglycinemia
SMP00244	Sarcosinemia