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MGP004845

UniProt Annotations

Entry Information
Gene Nameadenylate kinase 5
Protein EntryKAD5_HUMAN
UniProt IDQ9Y6K8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y6K8-1; Sequence=Displayed; Name=2; IsoId=Q9Y6K8-2; Sequence=VSP_037878; Note=It is unsure whether Met-1 or Met-5 is the initiator.; Name=3; Synonyms=Adenylate kinase 6; IsoId=Q9Y6K8-3; Sequence=VSP_037879;
Catalytic ActivityATP + AMP = 2 ADP.
Catalytic ActivityATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
FunctionNucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}.
SimilarityBelongs to the adenylate kinase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:19647735}.
SubunitMonomer. {ECO:0000250}.
Tissue SpecificityBrain specific.
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