MGP Database

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MGP004847

UniProt Annotations

Entry Information
Gene Nameglyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Protein EntryG3PT_HUMAN
UniProt IDO14556
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityD-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH. {ECO:0000255|PROSITE-ProRule:PRU10009}.
DomainThe testis-specific N-terminal extension mediates tight association with the cytoskeletal fibrous sheath of the spermatozoa flagellum, possibly via interchain disulfide-bonding of Cys-21 with sheath components. {ECO:0000269|PubMed:18298375}.
FunctionMay play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). {ECO:0000250}.
PathwayCarbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 1/5.
SimilarityBelongs to the glyceraldehyde-3-phosphate dehydrogenase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomotetramer. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. {ECO:0000269|PubMed:16820410, ECO:0000269|PubMed:18298375, ECO:0000269|PubMed:21269272}.
Tissue SpecificityTestis specific.
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