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MGP004873

UniProt Annotations

Entry Information
Gene Nameprocollagen C-endopeptidase enhancer 2
Protein EntryPCOC2_HUMAN
UniProt IDQ9UKZ9
SpeciesHuman
Comments
Comment typeDescription
FunctionBinds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. {ECO:0000269|PubMed:12393877}.
PtmO-glycosylated; contains sialic acid. {ECO:0000269|PubMed:12393877}.
SimilarityContains 1 NTR domain. {ECO:0000255|PROSITE- ProRule:PRU00295}.
SimilarityContains 2 CUB domains. {ECO:0000255|PROSITE- ProRule:PRU00059}.
Subcellular LocationSecreted {ECO:0000305}.
SubunitInteracts with heparin with high affinity, and type I or II collagen. {ECO:0000269|PubMed:12393877}.
Tissue SpecificityHighly expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea and placenta and weakly expressed in the brain. Expressed in cartilage. {ECO:0000269|PubMed:10873381, ECO:0000269|PubMed:11597177, ECO:0000269|PubMed:12393877}.
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