MGP Database

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MGP004895

Ontology/Pathway Information

Entrez Gene ID26986
Gene Namepoly(A) binding protein, cytoplasmic 1
Gene Symbol PABPC1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0071013 IDA:UniProtKBCcatalytic step 2 spliceosome
GO:0005737 TAS:UniProtKBCcytoplasm
GO:0036464 IDA:ParkinsonsUK-UCLCcytoplasmic ribonucleoprotein granule
GO:0010494 IDA:UniProtKBCcytoplasmic stress granule
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0016020 IDA:UniProtKBCmembrane
GO:0005634 IDA:MGICnucleus
GO:0030529 IDA:UniProtKBCribonucleoprotein complex
GO:0000166 IEA:InterProFnucleotide binding
GO:0008143 TAS:UniProtKBFpoly(A) binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0008266 IDA:MGIFpoly(U) RNA binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0008494 TAS:UniProtKBFtranslation activator activity
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0010467 TAS:ReactomePgene expression
GO:0031047 ISS:UniProtKBPgene silencing by RNA
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0006378 TAS:UniProtKBPmRNA polyadenylation
GO:0000398 IC:UniProtKBPmRNA splicing, via spliceosome
GO:0048255 TAS:UniProtKBPmRNA stabilization
GO:2000623 IDA:UniProtKBPnegative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288 TAS:ReactomePnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000184 TAS:ReactomePnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000289 TAS:ReactomePnuclear-transcribed mRNA poly(A) tail shortening
GO:1900153 ISS:UniProtKBPpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0060213 ISS:UniProtKBPpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0045727 TAS:GOCPpositive regulation of translation
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0006412 TAS:ReactomePtranslation
GO:0006413 TAS:ReactomePtranslational initiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1258Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
REACT_25325AUF1 (hnRNP D0) destabilizes mRNA
REACT_2099Cap-dependent Translation Initiation
REACT_20639Deadenylation-dependent mRNA decay
REACT_20514Deadenylation of mRNA
REACT_2159Eukaryotic Translation Initiation
REACT_71Gene Expression
REACT_79L13a-mediated translational silencing of Ceruloplasmin expression
REACT_17015Metabolism of proteins
REACT_75886Nonsense-Mediated Decay (NMD)
REACT_75822Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
REACT_75768Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_1014Translation
REACT_1979Translation initiation complex formation
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