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MGP004896

UniProt Annotations

Entry Information
Gene Namecytoplasmic FMR1 interacting protein 2
Protein EntryCYFP2_HUMAN
UniProt IDQ96F07
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96F07-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:10449408}; IsoId=Q96F07-2; Sequence=VSP_052349;
FunctionInvolved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. {ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}.
InductionBy p53/TP53. {ECO:0000269|PubMed:17245118}.
InteractionQ06787:FMR1; NbExp=2; IntAct=EBI-2433893, EBI-366305;
Rna EditingModified_positions=320 {ECO:0000269|PubMed:10574461, ECO:0000269|PubMed:11230166, ECO:0000269|PubMed:15731336}; Note=Partially edited. Editing appears to be brain-specific. {ECO:0000269|PubMed:15731336};
Sequence CautionSequence=BAA86482.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97324.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the CYFIP family. {ECO:0000255}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:17245118}. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:17245118}.
SubunitInteracts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex. {ECO:0000269|PubMed:15048733}.
Tissue SpecificityExpressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level). {ECO:0000269|PubMed:15048733}.
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