Log in / Register

MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MGP004900

UniProt Annotations

Entry Information

Gene Name	nerve growth factor receptor (TNFRSF16) associated protein 1
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q00994-1; Sequence=Displayed; Name=2; IsoId=Q00994-2; Sequence=VSP_046343; Note=No experimental confirmation available.;
Domain	The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR. {ECO:0000250}.
Function	May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. {ECO:0000250}.
Interaction	Q92574:TSC1; NbExp=5; IntAct=EBI-741753, EBI-1047085;
Miscellaneous	Binds transition metals. {ECO:0000250}.
Ptm	Ubiquitinated. Degraded by the proteasome (By similarity). {ECO:0000250}.
Similarity	Belongs to the BEX family. {ECO:0000305}.
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity). {ECO:0000250}.
Subunit	Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC (By similarity). Binds to the DEATH domain of p75NTR/NGFR. {ECO:0000250}.
Tissue Specificity	Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. {ECO:0000269\|PubMed:15958283}.