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MGP004922

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate-5-phosphatase J
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15735-1; Sequence=Displayed; Name=2; IsoId=Q15735-2; Sequence=VSP_007296; Name=3; IsoId=Q15735-3; Sequence=VSP_021017; Note=No experimental confirmation available.;
Catalytic Activity1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
Catalytic ActivityD-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
DomainThe 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.
FunctionInositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAD15618.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Note=Predominantly localized to membrane ruffles. {ECO:0000250}.
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