MGP Database

MGP004924

Record overview

MGPD ID	MGP004924
Gene ID	27131
Species	Homo sapiens (Human)
Gene Name	sorting nexin 5
Gene Symbol	SNX5
Alternate names	sorting nexin-5;
Chromosome	20
Map Location	20p11
Summary	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Orthologs	View orthologs and multiple alignments for SNX5

Proteins

sorting nexin-5 isoform a

Refseq ID:	NP_689413
Protein GI:	23111047
UniProt ID:	Q9Y5X3
mRNA ID:	NM_152227
Length:	404
RefSeq Status:

MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFD
GPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFT
GVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYML
NIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDL
FKNN

sorting nexin-5 isoform a

Refseq ID:	NP_055241
Protein GI:	7657599
UniProt ID:	Q9Y5X3
mRNA ID:	NM_014426
Length:	404
RefSeq Status:

sorting nexin-5 isoform b
Protein sequence is identical to GI:23111047 (mRNA isoform)

Refseq ID:	NP_001269383
Protein GI:	540344544
UniProt ID:	Q6P5V6
mRNA ID:	NM_001282454
Length:	299
RefSeq Status:

`MQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEV DDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAA KDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN`